For many people, this word conjures images of the food we eat and the way it is converted into energy for our bodies. However, metabolism on the molecular level encompasses all of the biochemical processes that allow cells to build and break down biomolecules, process sources of energy, and get rid of waste materials. Everything, from the smallest conversion between two closely related molecules to the large molecular assemblies that make up the structure of the cell, is a part of the broad metabolic picture of the cell. All metabolic activities are at the very core of cellular “life” — without them, the cell would not survive.
The Pagliarini lab is committed to discovering new pieces of metabolism and creating a holistic picture of cellular function. I am proud to have been a part of this process by focusing closely on enzymes and enzymatic function, which I believe are at the heart of biochemistry as a discipline now and into the future. My experiences have guided me into my intended career path, where I hope to make a difference for individuals affected by rare diseases, as well as their families and caregivers.
ACAD10 and ACAD11 enable mammalian 4- hydroxy acid lipid catabolism.
Edrees H. Rashan#, Abigail K. Bartlett#, Daven B. Khana, Jingying Zhang, Raghav Jain, Andrew J. Smith, Zakery N. Baker, Taylor Cook, Alana Caldwell, Autumn R. Chevalier, Brian F. Pfleger, Peng Yuan, Daniel Amador-Noguez, Judith A. Simcox, and David J. Pagliarini
(# These authors contributed equally.)
Ludovic Pelosi, Laura Morbiato, Arthur Burgardt, Fiorella Tonello, Abigail K. Bartlett, Rachel M. Guerra, Katayoun Kazemzadeh Ferizhendi, Maria Andrea Desbats, Bérengère Rascalou, Marco Marchi, Luis Vázquez-Fonseca, Caterina Agosto, Giuseppe Zanotti, Morgane Roger-Margueritat, María Alcázar-Fabra, Laura García-Corzo, Ana Sánchez-Cuesta, Plácido Navas, Gloria Brea-Calvo, Eva Trevisson, Volker F. Wendisch, David J. Pagliarini, Leonardo Salviati, Fabien Pierrel